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Stereophonic (Pantages/BiH)There’s an adage that goes something like: Sausage is tasty, but you don’t want to see how it is made. If there is a short summary of “Stereophonic“, which we saw last night at the Hollywood Pantages as part of the Broadway in Hollywood season, that would be it.

Going into this show, I didn’t know what to expect. Coming into the 2024 Tony awards, it had loads of buzz. Loads of Tony nominations. According to Wikipedia: “13 overall nominations at the 77th Tony Awards, breaking the record previously held by the Jeremy O. Harris play Slave Play (2020) to receive the most nominations for a play in the history of the ceremony; The play proceeded to win five awards: Best Play (which it also won at the Drama Desk Award, the Drama League Award, the Outer Critics Circle Award, and the New York Drama Critics’ Circle Award), Best Direction of a Play, Best Featured Actor in a Play (for Will Brill; Eli Gelb and Tom Pecinka also received nominations for the award), Best Scenic Design of a Play and Best Sound Design of a Play. Juliana Canfield and Sarah Pidgeon both received nominations for Best Featured Actress in a Play.”

The Broadway production received excellent reviews. I had gotten the album and was underwhelmed, but then again: This was a play with music, not a musical. So based on the Tony awards, and the performance at the Tony Awards, I was looking forward to the show. But then I started reading the comments when Broadway in Hollywood was posting about the show on Facebook. Comments like:

“Most nominated play in theater? Then theater is dead. Our entire group left at intermission tonight.”.

“I saw some comments before we saw it on Tuesday that the Pantages is too big for this particular show. And after leaving at Intermission (which we’ve NEVER done before), I’d have to agree. 1/4 of the stage was cut off for us and the play was incredibly slow.”

“Was really looking forward to this production. I’ve had season tickets for years here, and have been going to theater my entire life. I have NEVER walked out of a production before. We left at intermission.”

The pre-show buzz was so bad that Broadway in Hollywood felt the need to manage expectations, sending out an email that said to expect “cinematic, almost documentary-style pacing” and “Stereophonic paces in real time with conversations that overlap, spark, and erupt”, noting “Trust the silence. Sometimes the quietest moments are the loudest.”

But, then again, I also saw comments praising the show. So I really didn’t know what to expect going in. Would this be a disaster on the level of “Girl From the North Country”? Would this be spectacular, on the level of “To Kill A Mockingbird” (the last non-musical to play the Pantages)? I just didn’t know. All I really knew is that this was a play based on the making of a record album, supposedly based on Fleetwood Mac and the creation of the 1977 album “Rumours”, and that the Broadway running time of 3 hours, 10 minutes had been cut to 2 hours, 50 minutes.

So, here are my thoughts:

First, I think this was very much a case of a good show in the wrong theatre, with the wrong audience. The Broadway in Hollywood audience has been trained on musicals, with the best reception for spectacular, uplifting musicals. This was a dark (in theme) downer of a show. It wasn’t musical. It had slow pacing, with a documentary style, meaning the story wasn’t spoon fed to the audience. It had a single set that was boxed-in on the stage, meaning that much was lost in the cavern that is the Pantages. In short: This wasn’t playing to an audience that was receptive to the story, and the theatre was so big it swallowed the performances. These were two fatal flaws that doomed the reception of the show for much of the Pantages audience. “Stereophonic” would have been received much better on the Ahmanson stage; it might even have been acclaimed had it be done in one of Los Angeles’ mid-size prestige houses such as the Pasadena Playhouse or the Geffen.

Second, reviews were right in that it was a bit slow in its pacing. Taking a show on tour allows the production team a chance to review and improve the production for its eventual long life. A prime example of this is “The Addams Family”. That show had book and pacing problems on Broadway. It was revisited for the tour, and the result was a production that is now extremely popular and is being done everywhere. The production team of “Stereophonic” wisely cut out 30 minutes in preparing the tour version, as noted in the program. I think they could have tightened the production just a bit more.

Thirdly, this was not a production for everyone. There was strong language, there was reference to sex and drugs and rock and roll. There were fights. There was overtalking. There was silence. This wasn’t a feel-good show. The characters ended the show in a different place than where they started, but it was arguably a much worse place in terms of relationships and the band’s future. Those looking for a light musical would be disappointed. Those looking for a traditional play with a traditional structure and storytelling would be disappointed. This was a play for a more sophisticated audience who were willing to tough it out for a good conclusion.

That said: This wasn’t a “I Caligula: An Insanity Musical” level train-wreck. It wasn’t a “Girl from the North Country” level disaster. It was even better than mediocre. I was interested in the characters, and what happened to them. The story was interesting, and the behind-the-scenes of the making of an album was interesting. It clearly is a pressure cooker, and a good environment for story telling. It could have used a bit more dramatization to clarify the story and heighten interest. It probably had more relevance for those familiar with Fleetwood Mac and the “Rumours” album (I think I might have one Fleetwood Mac album in my library — it is a group I never knowingly listened to).

If I had to rate it, it was on the level of “OK” to “good”. I enjoyed the story, but I don’t really have a desire to see it again. But this clearly is a play not for everyone. I did like the Four Rules for Engineers stated early on in the show: 1. Show up. 2. Pay Attention. 3. Tell the truth. 4. Deal with the consequences

The performances were strong. I particularly liked Jack Barrett’s Grover, Claire Dejean’s Diana, and Denver Milord’s Peter.

“Stereophonic” continues at the Hollywood Pantages until January 2, 2026. You can get tickets through the Pantages website. Be forewarned that this isn’t a show for everyone: There were a number of people that left before and during intermission.

Other December Live Performances

You may have noticed a dearth of reviews during December. Part of that was due to the Annual Computer Security Applications Conference, which was in Waikiki the week of December 8, and prevented us from seeing shows the first and second weekends of December. However, while at the Conference, we did see the Pa’ina Waikiki Luau at Waikiki Beach Marriott. We actually coordinated the attendance of a group of 245 conference attendees at the luau. The luau itself was spectacular, with hulu, island stories, fire dancing, and all other sorts of traditional dances. Of course, the best was when we quietly engineered for our conference chair to join the dancing on stage. I have heard there are videos of this, but I don’t have the links.

After we returned, we saw two live concert performances. I normally don’t review concert performances, but I’m listing them for completeness:

  • Ben Platt: Live at the Ahmanson. I went in expecting this to be mostly Broadway music. Instead, it drew heavily from Ben’s solo albums and songwriting. It was an enjoyable show, and those more familiar with Ben’s music were really rocking out to it.
  • Nochebuena: A Christmas Spectacular at the Soraya. This production featured Ballet Folklórico de Los Ángeles, Mariachi Pueblo Viejo from Tucson, and had as a special guest Ximena Sariñana. I didn’t understand much of the words, but the dance was spectacular.

Lastly, the Christmas period concluded as halachicly required, with two movies: “Wicked: For Good” and “Song Sung Blue”. Both were excellent.

Credits

Stereophonic. Written by David Adjmi. Original songs by Will Butler. Directed by Daniel Aukin.

Cast: Jack Barrett Grover; Claire Dejean Diana; Steven Lee Johnson Charlie; Emilie Kouatchou Holly; Cornelius McMoyler Simon; Denver Milord Peter; Christopher Mowod Reg. Understudies: Jake Regensburg u/s Grover, u/s Reg; Quinn Allyn Martin u/s Diana; Andrew Gombas u/s Charlie, u/s Peter; Lauren Wilmore u/s Holly; Eli Bridges u/s Simon.

Production and Creative: David Adjmi Playwright; Will Butler Original Songs and Orchestrations; Daniel Aukin Director; David Zinn Scenic Design; Enver Chakartash Costume Design; Jiyoun Chang Lighting Design; Ryan Rumery Sound Design; Robert Pickens & Katie Gell Hair and Makeup Design; Justin Craig Music Director and Orchestrations; Alldaffer & Donadio Casting Casting; Gigi Buffington Vocal, Text, and Dialect Coach; Dylan Glen General Manager; Brian Decaluwe Company Manager; Geoff Maus Production Stage Manager; Holly Adam Stage Manager; Work Light Productions Production Management; Bond Theatrical Tour Booking, Marketing & Publicity; Ray Wetmore & JR Goodman Production Props Supervisor; Ann James Intimacy Coordinator; Drew Leary Fight Director.

Favorite Minor Credit: Work Light Productions Tax Credit Consultant.

Administrivia

I am not a professional critic. I’m a cybersecurity professional, a roadgeek who does a highway site and a podcast about California Highways, and someone who loves live performance. I buy all my own tickets, unless explicitly noted otherwise. I do these writeups to share my thoughts on shows with my friends and the community. I encourage you to go to your local theatres and support them (ideally, by purchasing full price tickets, if you can afford to do so). We currently subscribe or have memberships at: Center Theatre Group/Ahmanson TheatreBroadway in Hollywood/Pantages TheatrePasadena PlayhouseThe Soraya, Chromolume Theatre NEW, and 5-Star Theatricals. We just added Chromolume Theatre as our intimate theatre subscription — we subscribed there pre-pandemic when they were at their West Adams location, but they died back in 2018. They started back up last year (but we had seen all their shows); this year, their season is particularly interesting: The Color Purple, If/Then, Elegies (during Hollywood Fringe), and Roadshow (nee Bounce) [by Steven Sondheim]. Mind you, these are all in the intimate theatre setting, and this will be the first time Roadshow has been done in Los Angeles, to my knowledge. Information on purchasing their 2026 season is here. Our previous intimate theatre, Actors Co-Op, seems to be on hiatus.

I used to do more detailed writeups; here’s my current approach.

Upcoming ♦ Theatre / ♣ Music / ◊ Other Live Performance – Next 90ish Days (⊕ indicates ticketing is pending).

===> Click Here To Comment <==This entry was originally posted on Observations Along the Road as Sausage Making | "Stereophonic" @ BiH/Pantages by cahwyguy. Although you can comment on DW, please make comments on original post at the Wordpress blog using the link to the left. You can sign in with your LJ, DW, FB, or a myriad of other accounts. Note: Subsequent changes made to the post on the blog are not propagated by the SNAP Crossposter; please visit the original post to see the latest version. P.S.: If you see share buttons above, note that they do not work outside of the Wordpress blog.

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As you know, it is a halachic tradition to see a movie on Christmas Day, followed by Chinese Food. We arranged the Chinese Food through our synagogue’s brotherhood, but it was up to us to pick the movies. Normally, we’re live theatre folks: If you follow my blog at all, you know that we see live theatre or other forms of live performance almost every week (on average). But movies, in a movie theater? That’s reserved for the week around Christmas. I also don’t feel the need for full writeups (as I do with stage shows) for movies, especially given the size of the production team compared to live theatre production teams. That’s why IMDB exists. So here are some thoughts about the movies we saw this holiday season.

Wicked: For Good

Wicked: For Good (Movie)GIven that last year’s holiday movie was “Wicked: Part 1,  it is probably no surprise that this year’s pair of holiday movies started out with “Wicked: For Good” on Erev Christmas. Before we get started on the movie itself, a small bitch about the titles: I get that the producers changed their mind on the title after the first movie was released, but the fact that there’s a Part 1 without a Part 2 just gnaws at my brain. If an autauer as great as George Lucas can retitle “Star Wars” to “Star Wars Episode IV: A New Hope” after its release, then you can fix the title mismatch. Rename one of the parts of make things consistent. Ideally, the solution would be something along the lines of: “Wicked (Act 1): Defying Gravity” and “Wicked (Act 2): For Good”. With that off my chest…

This is a movie. This means that much of the audience was unfamiliar with the original musical by Winnie Holzman and Stephen Schwartz, let alone the original books by Gregory Maguire. This also means that they went into the movie expecting a continuation of the lightness and humor of the first movie. They didn’t get it. I felt bad for the family sharing our row at the theatre who brought their smalls (under 10 years old) with them. They were scared by the darkness, and bored by the love story, and as a result, were crying and couldn’t sit still. Folks: Act 2 of “Wicked” is dark. It was extremely dark in the original book, and just a bit lighter in the stage production, but is dark none-the-less. Folks should expect this, even given the MGM film. The focus of the story, the “Wicked Witch”, dies in the end. This can’t be a light story where the two girlfriends go skipping down the path together.

Gregory Maguire wrote his original book (which was the first of four in the series) as a political allegory during the Clinton administration. According to Wikipedia, while living in London in the early 1990s, he noticed that while the problem of evil had been explored from many different perspectives, those perspectives were seldom synthesized together. He wondered whether calling a person evil might be enough to cause a self-fulfilling prophecy. He decided to use the milieu of Oz to explore the story: hence, “Wicked”. His politics got more pointed in the later books: In particular, his second book in the series “Son of a Witch”, explores the political torture of the second Bush administration. The musical changed the story quite a bit (especially the ending), but kept the political themes, and the Act 2 movie leaned into that even more.

I mention this all because this really shows the adaptability of Oz. L. Frank Baum wrote the original story (before he started the rest of the children book series) as a political allegory about the McKinley administration and the silver standard (hence the silver shoes). Maguire wrote his first story exploring what makes people evil, as well as the nature of the power of propaganda and attacks on class. Yet viewing the story today, it is a wonderful commentary on the Trump administration, the administration’s manipulation of “truth”, and of the harnessing of hatred of a particular subclass of citizens to gain and retain power. The Wizard’s song “Wonderful” exposes this well, and is perhaps the political heart of the story (the emotional heart, as always, is the relationship between Elphaba and Glinda). I’m sure that much of the audience was unaware of this political message going in: Hopefully, they will learn from it. We are still dealing with the Carney who is running a government based on carnival flim-flam alone (and no real skills, other than charm), who is making up and selling a story, and who is abusing contributing citizens to gain and retain power. Children’s stories are often used to teach adult lessons in disguise.

The performances in the movie were outstanding. Cynthia Erivo and Ariana Grande were great, and bought distinct personalities and exceptionally strong singing voices to the role. I always love Ethan Slater (who I’ll always think of a Spongebob from the Spongebob Musical), and Jonathan Bailey made a great Fiyero.

The movie made a number of changes to the original story (for example, Elphaba’s father was originally an itinerant preacher). The movie also expanded a number of parts of the story, and made many aspects of the connection to the 1939 movie a lot more explicit (certainly more explicit than in the musical). The transformations of the Tin Man and Scarecrow were particularly strong. I did like how the ending ties well to the original story and map of Oz (and that’s all I’ll say).

Lastly, as I noted in my original comment on Facebook, it is amazing how many people it takes to make a movie, especially when compared to a stage production. The production team for the stage consists of perhaps 20 to 30 people, with perhaps another 20 in the costume and scenery shops. The Wicked movies listed at least 200 people, I’d guess.

One article I read noted that this movie was key for Universal, which viewed the movie as a tentpole franchise. Unlike their action movie or animation franchises, this movie appeals to women and brings them into the theaters. Hence, the intense and almost overwhelming marketing blitz for the pair of movies, which continues unabated. I’ve already heard rumors that there will be more movies in this franchise, although it is unclear in what direction they will go. It is hard to imagine them continuing with Maguire’s remaining 3 books (“Son of a Witch”, “A Lion Among Men”, and “Out of Oz”), simply because of their darkness, political intrigue, and work required to musicalize them. More likely would be Oz-adjacent stories set in the Maguire/Holzman universe, with new music. I’m not sure those will succeed, but given the desire of the audience, they probably will. Get ready for “Wicked: The Sparkly and the Furious”.

An excellent movie, well worth seeing. I predict that this pair of movies will continue to be shown and reshown on your television screens for a long time, just like the ubiquitous “Back to the Future”.

Song Sung Blue

Song Sung Blue (Movie)When I first heard about the movie “Song Sung Blue” and saw advertising for it, I was afraid it would be another Neil Diamond bio-pic. This didn’t interest me at all, as I had recently seen the excellent “A Beautiful Noise” at the Pantages. I also had no interest in seeing Jackman, whose musical star was tainted by the mess with Sutton Foster (who I think is a wonderful Broadway artist). But when my daughter was in town last week, she suggested that we go see “Song Sung Blue”, indicating that my concerns were misplaced. In particular, it was NOT a Neil Diamond bio-pic; rather, it was a story about two real Neil Diamond interpreters and was based on real life.

In parallel, I started reading some stories in the NY Times about Kate Hudson’s performance,  and how it was particularly strong.  As that article starts:

She’s a middle-aged, blue-collar amputee who sings backup in a kitschy Neil Diamond cover band. “I don’t want to be a hairdresser,” she says with a heavy Wisconsin accent. “I want to sing and dance.”

It’s not exactly a role that shouts Oscar. At first glance, it reads more like Razzie bait.

But the right actress in the right part: As played by Kate Hudson in the musical bio-dramedy “Song Sung Blue,” arriving in theaters on Christmas Day, the character, Claire, transcends her movie-of-the-week attributes — so much so that Hudson could land in the best actress race at the Academy Awards.

This sounded intriguing. I could overlook Hugh Jackman for that. So we booked tickets for this movie as our Christmas Day movie. I’m really glad we did.

This movie tells the story of Mike and Claire Sardina, who became famous as Lightning and Thunder, a group that interpreted Neil Diamond music at state fairs in the midwest, going so far as to open for Pearl Jam (yes, that’s true). Mike was a down-on-his-luck cover impersonation artist. He meets Claire, another such artist, and falls for her professionally and emotionally. The movie explores their ups and downs, and how music was the heart of their relationship. It is based mostly on real life, although there were a few changes from the real story of the Sardina’s. I found the story compelling, although the way the director presented the story there was almost too much foreshadowing. Some of the plot beats were predictable from the telegraphing alone (unlike real life). The movie would almost have been stronger without them (although it does make me curious to see the original 2008 documentary).

Hugh Jackman’s performance was good, and he makes a credible Neil Diamond impersonator. However (and this is especially true listening to the soundtrack of the movie in isolation), his Australian accent comes slightly through (e.g., at times I thought I was listening to Peter Allen singing Neil Diamond). If you don’t get that reference, Hugh Jackman burst onto the stage as a singer through the musical “A Boy from Oz“, which tells the story of Peter Allen). I don’t recall that accent coming through in “The Greatest Showman”, but now I’ll listen for it. His acting was very strong. For those that know him only from Wolverine, this might be a shock. For those that know him from stage or Showman, it is less of a surprise. He does bring quite a bit of depth to the role.

Kate Hudson is remarkable. I had no idea she was that strong of singer: she handles both the Neil Diamond and the Patsy Cline numbers with aplomb. Her performance, as the Times noted, was Oscar-worthy. She becomes Claire Sardina — and unlike a lot of actresses, is unafraid to do scenes sans makeup and showing her real age and vulnerability. She brings the character alive through performance alone. In some ways, this is unsurprising given her parents. But it also shows that she has been underestimated by the Hollywood machine. Hopefully, this will open more doors for her and a wider range of options.

Other performances were equally strong: I didn’t realize until the credits that Jim Belushi was involved. I was also particularly taken by Ella Anderson as Rachel (Claire’s daughter) and King Princess (as Angelina, Mike’s daughter) and their relationship to their parents. Hudson Hensley was also strong as Dana, Claire’s other child. Dana’s status is quietly male in the movie: In the articles I’ve seen about the real-life Dayna, I’ve seen all sorts of pronouns being used. Again, this is a movie that will play to middle-America, perhaps making a statement about acceptance they don’t realize they are getting.

Again, this is a movie I strongly recommend.

And thus, our two movies for 2025 are achieved. We now return you to your regularly posted theatre reviews.

===> Click Here To Comment <==This entry was originally posted on Observations Along the Road as Holiday Traditions: Wickedness and Music | "Wicked: For Good" and "Song Sung Blue" by cahwyguy. Although you can comment on DW, please make comments on original post at the Wordpress blog using the link to the left. You can sign in with your LJ, DW, FB, or a myriad of other accounts. Note: Subsequent changes made to the post on the blog are not propagated by the SNAP Crossposter; please visit the original post to see the latest version. P.S.: If you see share buttons above, note that they do not work outside of the Wordpress blog.

on NFTs and the art market

Dec. 28th, 2025 01:52 pm
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[personal profile] totient
Remember NFTs?

To explain what NFTs really were, first it's necessary to understand the manipulation of the art market by billionaires. Simplified, it goes something like this:

Billionaire A buys, over the course of years or decades, a bunch of art by some artist whose work is worthwhile but affordable. It doesn't have to be the most worthwhile work out there. Billionaire B buys a bunch of art by some other artist. Maybe it's a hundred pieces at five to ten thousand dollars apiece, or maybe it's somewhat fewer, somewhat more expensive pieces, but for most artists it's going to cost less than a million dollars over that artist's lifetime to become the foremost collector of that artist's work.

Some time later, perhaps after the death of the artists in question, Billionaire A (or his heirs) sells one of the pieces of art to Billionaire B for millions of dollars, and Billionaire B likewise sells a piece to Billionaire A for a similar sum. Billionaires A and B then also each donate one of their pieces of art to a museum.

By selling the pieces, they establish a value for the rest of their collection, and that means they can take the full market value of the donated piece off of their income without having to recognize the capital gains on the donated piece. This offsets the capital gains on the sold piece, net tax liability zero. And the amount of cash they each had to shell out to buy the multi million dollar pieces also nets out to zero. But suddenly they each have a billion dollars worth of art with an established market value that they can use as collateral for a low interest loan so they can buy an island or a jet or a rape victim's silence or whatever else they feel like buying that day.

It's not just that the billionaires have gotten this money tax free. It's that they have mostly made up the money in question. It's not real! But they get to spend it anyway.

This massive distortion of the art market has all kinds of knock-on effects, some of them positive. At the very least, it establishes value to billionaires of supporting living artists in ways that might not be significant to them but are certainly significant to the artists. It puts some of the art in museums where people other than the billionaires get to see it. The massive loss of tax revenue outweighs these benefits, but there was still a benefit.

NFTs were a way to make this market distortion more efficient. But the invented value lost its plausibility and the market collapsed.

AI is like this: mostly a market distortion with some real benefits, outweighed as they may be by the downsides. But the current financial arrangements of the AI companies have gotten too efficient, and lost sight of the value plausibility.

Art survived the NFT implosion. I hope computers survive the AI implosion.

Went well

Dec. 28th, 2025 01:39 pm
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[personal profile] vvalkyri
I very much appreciate Marmota and Trowa Barton sending me pictures from Boston, and I've got some people I should send messages to.

It does look like it was a great party and I hope to reconnect with the post posts at some point and I had a pretty good day after all yesterday. It's not a bunch of time on the phone with a couple people and then
Tarek came here to pick me up and we first went swimming and then used the showers and then drove out there and got there part way through the lesson and if he hadn't kept disappearing I might have wanted to leave a lot earlier but I had some very good dances and met some cool people and got much more of an idea of bachata and even got a little Acro in. The instructor may try finding Acro.


Speaking of acro, it's 2:00 to 6:00 today and I was not planning on getting there anywhere near that early and I still have some goo in my hair that I need to wash out and I still need to actually eat anything...


Getting to sleep at 6:00 was not clever. And part of that was putting goo in my hair when I first got inside.

(no subject)

Dec. 27th, 2025 12:56 pm
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[personal profile] vvalkyri
I'm not sure I've ever had quite so much fomo about a single night event in another city. I would not have been able to leave DC until yesterday and as it turns out I have maintenance at 9a Monday to handle the shower leak I had thought was my fridge. (Which tells you how much parquet is toasted.). So flying would have been a mess and the huge SWA sale the flights weren't until Jan 8.

But damn I wish there were something specific really competing back here this weekend.

(It's not that I can't fill the time with things I need to do and with people I haven't seen for a while. Need to check in as to whether I'm going to Jewish Museum for the GBLT Jews in the capital city exhibit today. Glen Echo is dark. I have an invite to a different sort of dance tonight as well. )


But it's folks I really like and I don't necessarily see on other visits to that city and there's a whole lot of people I would really like to see and they would all be in one place.

And it's too late to drive. And honestly I don't know how much I trust Ms Olds for a drive that far. It's not like I haven't done that drive in one day a number of times. She's probably okay? But it didn't even dawn on me that driving could conceivably be a thing, because I have had so little brain all month. I mean granted it also sounds like they just had snow. And yesterday was supposed to be freezing rain here.


There's a whole lot of reasons I'm not up there and I hate it.

Just Create - Hacker Edition

Dec. 26th, 2025 09:49 pm
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[personal profile] silvercat17 posting in [community profile] justcreate
What are you working on? What have you finished? What do you need encouragement on?
 
Are there any cool events or challenges happening that you want to hype?
 
What do you just want to talk about?
 
What have you been watching or reading?
 
Chores and other not-fun things count!
 
Remember to encourage other commenters and we have a discord where we can do work-alongs and chat, linked in the sticky.

And the bells were ringing out.....

Dec. 25th, 2025 11:24 pm
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[personal profile] cz_unit
Was listening to the song Fairytale of New York with the family this evening, it's an old Pogues song and I remember liking it because I loved Kristi MacCool back in the day. But I guess I never really got it, and this evening, listening to the lyrics....

I suddenly got it.

And yeah, it is beautiful. And sad, and brings back memories from long ago. Long, long, long ago.

I kept them with me, babe, I put them with my own
Can't make it all alone, I've built my dreams around you

Long ago.....
siderea: (Default)
[personal profile] siderea
2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":
By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:
Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
Continuing from the article:
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.
The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):
Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

Quilted book cover

Dec. 22nd, 2025 04:29 pm
meningioma: (MISC - snow)
[personal profile] meningioma posting in [community profile] everykindofcraft
Made this little quilted book cover for my sister
Read more... )

Stick a fork in me, I'm done

Dec. 22nd, 2025 06:07 pm
a_cubed: caricature (Default)
[personal profile] a_cubed
In both senses, I am done for the calendar year with Universities work. Still lots of household work to do before and through Christmas, but having hoped to get finished with Marking Hell(TM) on Saturday I still had three essays to mark today. It seemed like Xeno's paradox at times, taking twice as long for each essay as the last. Having finished only two in two and a half hours this morning, I needed to take $OFFSPRING to the dentist, but finished the third while they are at a piano lesson just now.

Now, so very tired....Zzzz.

I may post the rest of this year's reading before the end of the year, or that may get left to January.

One note about watching. If you enjoy Japanese Anime at all, I highly recommend Dandadan. Such amazing fun I've watched the first two seasons multiple times already. The next season won't be until 2027 (though work on it is underway).

The ornament is finished!

Dec. 21st, 2025 10:16 pm
ladythmpr: (Art)
[personal profile] ladythmpr posting in [community profile] nacramamo
Back in this entry, I had finished stitching a cross stitch ornament. Nearly two months later, I finally completed all the finishing work and hung it on my tree! The instructions said to glue all the finishing bits together, but I sewed them instead.

20251210b 20251210c

20251217a 20251217b 20251217c

Just Create - Yokai Edition

Dec. 19th, 2025 10:25 pm
silvercat17: a green skeleton in a santa hat waving (skeleton santa)
[personal profile] silvercat17 posting in [community profile] justcreate
What are you working on? What have you finished? What do you need encouragement on?
 
Are there any cool events or challenges happening that you want to hype?
 
What do you just want to talk about?
 
What have you been watching or reading?
 
Chores and other not-fun things count!
 
Remember to encourage other commenters and we have a discord where we can do work-alongs and chat, linked in the sticky.

December Check-In

Dec. 18th, 2025 05:37 pm
yourlibrarian: Every Kind of Craft on green (Every Kind of Craft Green - yourlibraria)
[personal profile] yourlibrarian posting in [community profile] everykindofcraft


This month's post will be serving double duty as a community promo. I also run the [community profile] threeforthememories event, whose 2025 session will be open for posts on January 3, 2026 and will run for 3 weeks until January 24. Participant posts consist of 3 photos (only) you've taken of anything from 2025 that you find meaningful in some way or which represent how you experienced the year. These could be your crafting activities, or anything else you find relevant.

Questions? Visit the announcement post at [community profile] threeforthememories

This month's question involves the holidays. Do you normally do crafting over this period? Is it related to any holidays? Do you do craft gifting? And if so, what do you plan to gift this year?

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dianec42: Joshua tree against a blue sky (Default)
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